Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | DRD3 | P35462 | 8/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540526 | 0.91 | DRD2 (0.41) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL7544338 | 0.86 | ITGB3 (0.41) | ITGB3ITGA2BITGAV | |
| SCHEMBL6796559 | 0.86 | CASR (0.45) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL382964 | 0.83 | CASR (0.45) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL6800147 | 0.82 | ITGB3 (0.45) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL382117 | 0.80 | DRD2 (0.44) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL7540509 | 0.80 | CASR (0.42) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL6796240 | 0.80 | DRD2 (0.43) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL6801456 | 0.78 | DRD2 (0.41) | CASRDRD2DRD3ITGB3ITGA2B | |
| SCHEMBL382410 | 0.77 | ITGB3 (0.44) | CASRDRD2DRD3ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1209152-A1 | OMEGA-AMINO-ALPHA-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISM | MEIJI SEIKA KAISHA LTD. (JP) | 2002-05-29 | — | — | EP | claimed |
| US-6750219-B1 | HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISTIC ACTIVITY, GP IIB/IIIA ANTAGONISTIC ACTIVITY, AND/OR HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY AND ALSO HAVING EXCELLENT WATER SOLUBILITY | MEIJI SEIKA KAISHA, LTD. (JP) | 2004-06-15 | — | — | US | disclosed |
| EP-1209152-A1 | OMEGA-AMINO-ALPHA-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN ALPHA V BETA 3 ANTAGONISM | MEIJI SEIKA KAISHA LTD. (JP) | 2002-05-29 | — | — | EP | disclosed |