Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | MMP14 | P50281 | 4/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | FEN1 | P39748 | 4/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673020 | 0.89 | MMP7 (0.57) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6806495 | 0.89 | MMP7 (0.57) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6703175 | 0.88 | MMP7 (0.61) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6808740 | 0.86 | MMP7 (0.53) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6807839 | 0.84 | MMP7 (0.65) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6807846 | 0.84 | MMP7 (0.65) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6648549 | 0.83 | CYP3A4 (0.40) | MMP7MMP13CYP3A4DRD2DRD4 | |
| SCHEMBL6646070 | 0.83 | MMP7 (0.60) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL6644519 | 0.83 | MMP7 (0.66) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL13923650 | 0.81 | MMP13 (0.61) | MMP7MMP13CYP3A4MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180901-A1 | Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | US | claimed |
| US-20040180901-A1 | Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180901-A1 | Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents | MMP13, MMP3, MMP2 | MMP7 18/4885MMP13 1/4885CYP3A4 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.