Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.62 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.49 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.49 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.49 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.49 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.49 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.49 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.49 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.49 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.49 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.49 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.49 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.49 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.49 |
| ▸ | PSMA8 | Q8TAA3 | 2/20 | 0.49 |
| ▸ | PSMB7 | Q99436 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028150 | 0.89 | CTSS (0.61) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6807038 | 0.89 | CTSS (0.61) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6802848 | 0.89 | CTSS (0.61) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6799892 | 0.86 | CTSS (0.49) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6801406 | 0.79 | CTSS (0.62) | CTSSCTSBCTSKCTSLCTSH | |
| SCHEMBL6800727 | 0.78 | CTSS (0.53) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6917088 | 0.78 | CTSS (0.53) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6801801 | 0.75 | CTSS (0.61) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6801803 | 0.75 | CTSS (0.61) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6463431 | 0.75 | CTSL (0.56) | CTSSCTSBCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730671-B2 | ENZYME INHIBITOR TREATING AUTOIMMUNE DISEASES, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-05-04 | — | — | US | disclosed |
| US-20030158406-A1 | Compounds useful as reversible inhibitors of cathepsin S | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-08-21 | — | — | US | disclosed |
| US-6608057-B2 | Compounds useful as reversible inhibitors of cathepsin S | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20020091259-A1 | Compounds useful as reversible inhibitors of cathepsin S | CYWIN CHARLES L (US) | 2002-07-11 | — | — | US | disclosed |
| US-6395897-B1 | DRUGS FOR ENZYME INHIBITORS ANTICOAGULANTS AND TREATMENT OF AUTOIMMUNE DISEASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-05-28 | — | — | US | disclosed |
| EP-1159273-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051998-A1 | COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CATHEPSIN S | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091259-A1 | Compounds useful as reversible inhibitors of cathepsin S | CTSS, CTSB, CTSV | CTSS 1/4885PSMB11 452/4885PSMA7 422/4885 |
| US-20030158406-A1 | Compounds useful as reversible inhibitors of cathepsin S | CTSS, CTSB, CTSV | CTSS 1/4885PSMB11 452/4885PSMA7 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.