Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681505 | 0.86 | CNR2 (0.40) | SIGMAR1MC4RSMN1; SMN2TACR2MEN1 | |
| SCHEMBL684454 | 0.83 | ACACB (0.40) | MC4RSMN1; SMN2TACR2MEN1KMT2A | |
| SCHEMBL2738522 | 0.81 | PSEN1 (0.41) | MC4RSMN1; SMN2TACR2MEN1KMT2A | |
| SCHEMBL681504 | 0.74 | GPR142 (0.42) | MC4RTACR2KDM1AMAOAMAOB | |
| SCHEMBL680253 | 0.73 | SLC6A2 (0.46) | SMN1; SMN2MEN1KMT2AACACBSLC6A2 | |
| SCHEMBL681440 | 0.72 | SLC6A2 (0.44) | SMN1; SMN2MEN1KMT2AACACBCYP1A2 | |
| SCHEMBL12188589 | 0.71 | GPR142 (0.43) | TACR2KDM1AMAOAMAOBACACB | |
| SCHEMBL680881 | 0.71 | AVPR1A (0.41) | ACACBCCR2AVPR1AL3MBTL1 | |
| SCHEMBL684223 | 0.68 | CCR2 (0.41) | KMT2AACACBCCR2AVPR1A | |
| SCHEMBL681300 | 0.66 | AKT3 (0.47) | SMN1; SMN2MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |