Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684454 | 0.90 | ACACB (0.40) | TACR2CCR2AVPR1AKCNH2NPY1R | |
| SCHEMBL681505 | 0.85 | CNR2 (0.40) | TACR2CCR2AVPR1AKCNH2NPY1R | |
| SCHEMBL2738925 | 0.82 | LMNA (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL680259 | 0.81 | SIGMAR1 (0.37) | TACR2CCR2AVPR1ANPY1RNPY5R | |
| SCHEMBL12188589 | 0.78 | GPR142 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10266645 | 0.76 | ALDH1A1 (0.54) | TACR2KCNH2NPC1RAB9ALMNA | |
| SCHEMBL684223 | 0.74 | CCR2 (0.41) | CCR2AVPR1AKCNH2LMNAKMT2A | |
| SCHEMBL681504 | 0.74 | GPR142 (0.42) | TACR2CCR2AVPR1AMC4RCYP2C9 | |
| SCHEMBL7971029 | 0.70 | CYP2C19 (0.47) | LMNAMEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL2738906 | 0.70 | CYP2C19 (0.47) | LMNAMEN1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |