SCHEMBL6803059

SCHEMBL6803059

O=S(=O)(CCCC(O)=S)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC3 O15379 1/20 0.54
HDAC4 P56524 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC11 Q96DB2 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
HDAC9 Q9UKV0 1/20 0.54
HDAC5 Q9UQL6 1/20 0.54
HSD11B1 P28845 4/20 0.53
KEAP1 Q14145 1/20 0.51
NFE2L2 Q16236 1/20 0.51
KCNH2 Q12809 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
MMP3 P08254 2/20 0.47
MMP8 P22894 2/20 0.47
MMP13 P45452 2/20 0.47
MMP1 P03956 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5128861 0.82 HDAC1 (0.60) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL576918 0.81 KEAP1 (0.63) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL10629823 0.81 PSIP1 (0.61) HDAC1HDAC2HDAC8HDAC3HDAC4
Hydrochloric Acid SCHEMBL5120938 0.81 HDAC1 (0.58) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL2810870 0.81 HDAC1 (0.58) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL7773642 0.79 HDAC1 (0.57) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL1232793 0.79 HDAC1 (0.57) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL6803062 0.79 HDAC1 (0.57) HDAC1HDAC2HDAC8HDAC3HDAC4
Hydrochloric Acid SCHEMBL5124026 0.79 HDAC1 (0.57) HDAC1HDAC2HDAC8HDAC3HDAC4
SCHEMBL10626503 0.79 HDAC1 (0.65) HDAC1HDAC2HDAC8HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6828427-B1 Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same ISIS PHARMACEUTICALS, INC. 2004-12-07 US disclosed
US-6750344-B1 MONOCYCLIC AMINE SCAFFOLD BEARING AT LEAST TWO SITES OF DIVERSITY, CYCLIZED TO FORM BICYCLIC AMINE SCAFFOLDS; 7-AMINO-PYRROLO(1,2-A)PYRAZIN-4-ONE COMPOUNDS ISIS PHARMACEUTICALS, INC. 2004-06-15 US disclosed
US-6316626-B1 Amine compounds and combinatorial libraries comprising same ISIS PHARMACEUTICALS, INC. 2001-11-13 US disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
WO-1999012034-A1 AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME ISIS PHARMACEUTICALS, INC. (US) 1999-03-11 WO disclosed