Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30341108 | 0.98 | ALDH1A1 (0.73) | ALDH1A1GAAKDM4ESMN1; SMN2POLB | |
| SCHEMBL3262128 | 0.84 | ALDH1A1 (0.96) | ALDH1A1KDM4ESMN1; SMN2POLBCYP2A13 | |
| SCHEMBL6384809 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EPOLBCYP2A13 | |
| SCHEMBL3965653 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EPOLBCYP2A13 | |
| SCHEMBL2925434 | 0.84 | LMNA (0.54) | ALDH1A1GAAPOLBCYP2A13AR | |
| SCHEMBL11334386 | 0.83 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2POLBCYP2A13 | |
| SCHEMBL807350 | 0.82 | ALDH1A1 (1.00) | ALDH1A1KDM4ESMN1; SMN2POLBCYP2A13 | |
| SCHEMBL247774 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2POLBCYP2A13 | |
| SCHEMBL19634159 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2POLBCYP2A13 | |
| SCHEMBL3377345 | 0.81 | MPO (0.56) | ALDH1A1GAAKDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |