Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680514 | 0.87 | PLK4 (0.41) | MAPTMEN1KMT2AGLSPTGDR2 | |
| SCHEMBL680354 | 0.81 | ATM (0.47) | ATMMAPTLMNAHTTMEN1 | |
| SCHEMBL680501 | 0.77 | SCN9A (0.43) | MAPTGLSPTGDR2ALDH1A1 | |
| SCHEMBL681119 | 0.76 | ATM (0.54) | ATMMAPTLMNAHTTMEN1 | |
| SCHEMBL680999 | 0.76 | PLK4 (0.42) | — | |
| SCHEMBL23081442 | 0.74 | CCNT1 (0.42) | ATMMAPTGLSALDH1A1 | |
| SCHEMBL22353120 | 0.70 | F2 (0.49) | MAPTLMNAKMT2ASCN4AF2 | |
| SCHEMBL680764 | 0.70 | RXRA (0.40) | MAPTMCL1PTGDR2ALDH1A1HPGD | |
| SCHEMBL30896348 | 0.69 | HTR6 (0.48) | ATMMAPTLMNAHTTMEN1 | |
| SCHEMBL679247 | 0.69 | CYP11B1 (0.47) | MAPTGLSPTGDR2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |