Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680096 | 0.92 | SMN1; SMN2 (0.48) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL679907 | 0.90 | SCN9A (0.50) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL680561 | 0.89 | MMP13 (0.65) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL680466 | 0.87 | EZH2 (0.54) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL679760 | 0.84 | BCL2L1 (0.49) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL679703 | 0.84 | SCN9A (0.49) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL680791 | 0.83 | CA1 (0.61) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL16319859 | 0.81 | MMP1 (0.56) | SMN1; SMN2HTTHPGDTSHRSCN9A | |
| SCHEMBL703171 | 0.81 | BCL2L1 (0.59) | MMP13SMN1; SMN2HTTHPGDTSHR | |
| SCHEMBL678839 | 0.80 | PPARA (0.47) | MMP13SCN9APTPN1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MMP13 4543/4885SMN1; SMN2 282/4885HTT 1281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.