Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.45 |
| ▸ | SCN2B | O60939 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680496 | 0.92 | MMP13 (0.51) | SMN1; SMN2ALDH1A1CYP3A4MMP13SCN9A | |
| SCHEMBL680791 | 0.87 | CA1 (0.61) | SMN1; SMN2NPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL679907 | 0.85 | SCN9A (0.50) | SMN1; SMN2ALDH1A1KMT2AMMP13SCN9A | |
| SCHEMBL680286 | 0.85 | PGR (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL680561 | 0.84 | MMP13 (0.65) | SMN1; SMN2NPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL7985093 | 0.82 | CA1 (0.67) | SMN1; SMN2NPC1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL680466 | 0.82 | EZH2 (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL678507 | 0.79 | SCN9A (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL680757 | 0.79 | SCN9A (0.53) | SMN1; SMN2NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL679703 | 0.79 | SCN9A (0.49) | SMN1; SMN2MEN1KMT2AMMP13SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | SMN1; SMN2 282/4885NPC1 1918/4885RAB9A 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.