Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.48 |
| ▸ | SCN2B | O60939 | 2/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680496 | 0.87 | MMP13 (0.51) | HTTALDH1A1SCN9AMCL1BCL2L1 | |
| SCHEMBL680286 | 0.86 | PGR (0.60) | ALDH1A1SCN9ASCN2BSCN1ASCN1B | |
| SCHEMBL17171690 | 0.85 | HSD17B1 (0.56) | EZH2HTTTDP1L3MBTL1HSD17B1 | |
| SCHEMBL680561 | 0.85 | MMP13 (0.65) | HTTGFERALDH1A1SCN9AMCL1 | |
| SCHEMBL678903 | 0.85 | BCL2L1 (0.52) | L3MBTL1ALDH1A1SCN9ASCN2BSCN1A | |
| SCHEMBL678831 | 0.85 | BCL2L1 (0.52) | HTTALDH1A1SCN9ASCN2BSCN1A | |
| SCHEMBL679785 | 0.84 | MCL1 (0.62) | TDP1SCN9AMCL1BCL2L1HDAC8 | |
| SCHEMBL679703 | 0.83 | SCN9A (0.49) | HTTTDP1L3MBTL1GFERSCN9A | |
| SCHEMBL679782 | 0.83 | SCN9A (0.50) | HTTSCN9AMCL1BCL2L1SMN1; SMN2 | |
| SCHEMBL679983 | 0.83 | ACACB (0.50) | L3MBTL1MAPK1MCL1BCL2L1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | EZH2 4401/4885HTT 1281/4885TDP1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.