Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990728 | 0.90 | HDAC1 (0.59) | HTTSMN1; SMN2HDAC1HDAC6ALDH1A1 | |
| SCHEMBL365523 | 0.88 | BCL2L1 (0.59) | MMP13MAPK14HTTSMN1; SMN2MMP2 | |
| SCHEMBL16320154 | 0.86 | MMP1 (0.57) | MAPK14HTTSMN1; SMN2CYP3A4HPGD | |
| SCHEMBL363932 | 0.86 | BCL2L1 (0.56) | MMP13MAPK14HTTSMN1; SMN2MMP2 | |
| SCHEMBL680561 | 0.84 | MMP13 (0.65) | MMP13MAPK14HTTSMN1; SMN2MMP2 | |
| SCHEMBL7983736 | 0.82 | CA1 (0.62) | SMN1; SMN2CYP3A4HDAC1ALDH1A1MAPT | |
| SCHEMBL7985089 | 0.81 | PLK1 (0.65) | SMN1; SMN2HPGDALDH1A1MAPTCYP1A2 | |
| SCHEMBL21628916 | 0.80 | HDAC6 (0.77) | MMP13MAPK14HTTSMN1; SMN2MMP2 | |
| SCHEMBL365989 | 0.79 | BCL2L1 (0.50) | MMP13MMP2ALDH1A1NPC1MMP9 | |
| SCHEMBL7984813 | 0.79 | HDAC1 (0.53) | SMN1; SMN2HDAC1HDAC6ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MMP13 4543/4885MAPK14 1576/4885HTT 1281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.