Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810109 | 0.89 | AURKA (0.40) | PARP1KDRFGFR1PARP2AURKB | |
| SCHEMBL6801999 | 0.89 | AURKB (0.50) | PARP1KDRPARP2AURKBPRKD3 | |
| SCHEMBL6805702 | 0.85 | AURKA (0.48) | PARP1KDRHTR6AURKBAURKA | |
| SCHEMBL6805985 | 0.84 | PARP1 (0.56) | PARP1KDRPARP2AURKBPRKD3 | |
| SCHEMBL6810121 | 0.81 | HTR1A (0.41) | PARP1KDRAURKBPRKD3PIM1 | |
| SCHEMBL6806267 | 0.81 | HTR1A (0.43) | PARP1KDRHTR6AURKBPRKD3 | |
| SCHEMBL6806431 | 0.78 | PKN1 (0.42) | PARP1KDRFGFR1PARP2AURKB | |
| SCHEMBL3587289 | 0.78 | AURKA (0.56) | PARP1PARP2AURKBAURKA | |
| SCHEMBL5620750 | 0.77 | HTR3A (0.52) | PARP1KDRAURKBPRKD3PIM1 | |
| SCHEMBL6806351 | 0.77 | AURKA (0.59) | PARP1KDRPARP2AURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |