Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 3/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PRKX | P51817 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806139 | 0.83 | IKBKB (0.52) | PKN1PKN2CLK4CDK5DYRK1B | |
| SCHEMBL6809996 | 0.80 | PKN1 (0.63) | PKN1PKN2CLK4PLK4MAP4K4 | |
| SCHEMBL6806427 | 0.80 | PKN1 (0.67) | PKN1PKN2CLK4PLK4MAP4K4 | |
| SCHEMBL6806964 | 0.80 | PKN1 (0.65) | PKN1PKN2CLK4PLK4MAP4K4 | |
| SCHEMBL6805010 | 0.79 | METAP2 (0.53) | PKN1PKN2CLK4PLK4MAP4K4 | |
| SCHEMBL6806538 | 0.78 | PTGER1 (0.41) | LRRK2CHEK2PARP1DHODHHTT | |
| SCHEMBL6805989 | 0.78 | PARP1 (0.38) | CLK4AURKACSF1RFGFR1KDR | |
| SCHEMBL6805384 | 0.77 | CLK4 (0.44) | PKN2CLK4MAP4K4CDK5DYRK1B | |
| SCHEMBL27461815 | 0.76 | KDM4E (0.54) | CLK4PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL6806567 | 0.76 | CHEK2 (0.42) | PKN2CLK4MAP4K4CDK5DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |