Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28026807 | 0.79 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL5360302 | 0.79 | LMNA (0.78) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL401293 | 0.77 | CYP1A2 (0.48) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL6912864 | 0.76 | LMNA (0.32) | LMNASMN1; SMN2 | |
| SCHEMBL3691082 | 0.76 | LMNA (0.55) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8658127 | 0.76 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL28506559 | 0.75 | CYP1A2 (0.47) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL3439357 | 0.74 | KDM4E (0.51) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL568577 | 0.73 | KDM4E (0.69) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1346260 | 0.73 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693194-B2 | BY REACTING 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE IN AN INERT ORGANIC SOLVENT WITH AN ALKALI METAL METHOXIDE, TRANSFERRING TO AN AQUEOUS ACID MEDIUM AND OXIDATION; USING THE PRODUCT TO PREPARE 7-((4,6- | SYNGENTA CROP PROTECTION, INC. | 2004-02-17 | — | — | US | disclosed |
| US-20030135047-A1 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine | SYNGENTA CORP PROTECTION, INC. | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030135047-A1 | Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine | TPMT, DHODH, DPYD | LMNA 4325/4885SMN1; SMN2 897/4885ALDH1A1 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.