Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 13/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806906 | 0.84 | PARP1 (0.56) | PARP1ALOX15PLA2G2APTGS2DYRK1A | |
| SCHEMBL6585078 | 0.75 | PARP1 (0.44) | ALDH1A1HSD17B10PARP1ALOX15PLA2G2A | |
| SCHEMBL6806330 | 0.73 | MEN1 (0.60) | KDM4EALDH1A1HSD17B10LMNAPARP1 | |
| SCHEMBL8648025 | 0.73 | PARP1 (0.67) | PARP1CDK9DYRK1AFGFR1 | |
| SCHEMBL3579908 | 0.70 | PARP1 (0.61) | KDM4EALDH1A1PARP1DYRK1ACLK4 | |
| SCHEMBL31053400 | 0.70 | PARP1 (0.67) | PARP1ALOX15PLA2G2APTGS2CLK4 | |
| SCHEMBL17048129 | 0.69 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10PARP1DYRK1A | |
| SCHEMBL6806564 | 0.68 | ADORA3 (0.54) | PARP1FGFR1KDRCLK4 | |
| SCHEMBL6802033 | 0.68 | FGFR1 (0.51) | KDM4EALDH1A1LMNAPARP1FGFR1 | |
| SCHEMBL6805414 | 0.68 | PLK4 (0.39) | PARP1FGFR1KDRCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |