Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806583 | 0.87 | PARP1 (0.57) | PARP1DHODHPKN1PKN2PLK4 | |
| SCHEMBL6586959 | 0.84 | KDM4E (0.56) | PARP1KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL6810278 | 0.82 | PIM1 (0.54) | PARP1DHODHPRKD3MAP4K4PIM1 | |
| SCHEMBL6806949 | 0.82 | KDM4E (0.59) | PARP1KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL6801381 | 0.80 | L3MBTL1 (0.51) | PARP1KDM4EDHODH | |
| SCHEMBL6802028 | 0.77 | PARP1 (0.66) | PARP1DHODHPKN1PKN2PLK4 | |
| SCHEMBL29411925 | 0.77 | PARP1 (0.72) | PARP1DHODHPKN1PKN2PLK4 | |
| SCHEMBL6805760 | 0.77 | PARP1 (0.51) | PARP1DHODH | |
| Hydrochloric Acid SCHEMBL6809753 | 0.75 | PARP1 (0.60) | PARP1DHODHPKN1PKN2PLK4 | |
| SCHEMBL6801937 | 0.74 | PARP1 (0.58) | PARP1DHODHPKN1PKN2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |