Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806586 | 0.87 | HTT (0.46) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL6810283 | 0.82 | PARP1 (0.42) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL6806945 | 0.82 | PARP1 (0.60) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL6801383 | 0.80 | L3MBTL1 (0.51) | KDM4EHTT | |
| SCHEMBL27461815 | 0.75 | KDM4E (0.54) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL6802033 | 0.75 | FGFR1 (0.51) | KDM4EALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL6801942 | 0.74 | MAPT (0.40) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL8648025 | 0.74 | PARP1 (0.67) | CDC7PARP1 | |
| SCHEMBL3579908 | 0.73 | PARP1 (0.61) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL2292691 | 0.73 | KDM4E (0.54) | KDM4ENPC1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |