Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806949 | 0.87 | KDM4E (0.59) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6806583 | 0.83 | PARP1 (0.57) | PARP1 | |
| SCHEMBL6810283 | 0.78 | PARP1 (0.42) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6801383 | 0.78 | L3MBTL1 (0.51) | HTTKDM4EPOLB | |
| SCHEMBL27461815 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL6802033 | 0.74 | FGFR1 (0.51) | KDM4EALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL8648025 | 0.72 | PARP1 (0.67) | PARP1CDC7 | |
| SCHEMBL3579908 | 0.72 | PARP1 (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL6587773 | 0.72 | PARP1 (0.46) | HTTCREBBPBRPF1BRD9KDM4E | |
| SCHEMBL30394690 | 0.71 | CREBBP (0.58) | HTTCREBBPBRPF1BRD9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |