Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678827 | 0.90 | SCN9A (0.58) | MAPK14SCN9ASCN5ANPC1RAB9A | |
| SCHEMBL680717 | 0.85 | MAPK14 (0.56) | MAPK14SCN9ASCN5ARAB9ASMN1; SMN2 | |
| SCHEMBL680286 | 0.84 | PGR (0.60) | SCN9ASCN5ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16319793 | 0.84 | SCN9A (0.54) | SCN9ASCN5ANPC1RAB9ALMNA | |
| SCHEMBL678831 | 0.83 | BCL2L1 (0.52) | SCN9ASCN5ANPC1RAB9AHDAC8 | |
| SCHEMBL366467 | 0.82 | MMP2 (0.60) | MAPK14SCN9ASCN5AKAT6A | |
| SCHEMBL680539 | 0.82 | HDAC8 (0.47) | MAPK14SCN9ASCN5ANPC1RAB9A | |
| SCHEMBL369173 | 0.82 | MAPK14 (0.53) | MAPK14SCN9ASCN5ANPC1RAB9A | |
| SCHEMBL680466 | 0.82 | EZH2 (0.54) | SCN9ASCN5ANPC1RAB9AHDAC8 | |
| SCHEMBL16319439 | 0.81 | MAPK14 (0.56) | MAPK14NPC1RAB9AHDAC8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |