Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.55 |
| ▸ | SCN2B | O60939 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680791 | 0.88 | CA1 (0.61) | SMN1; SMN2NPC1ALDH1A1TP53RAB9A | |
| SCHEMBL680466 | 0.86 | EZH2 (0.54) | SCN2BSCN1ASCN1BSCN5ASCN9A | |
| SCHEMBL679983 | 0.85 | ACACB (0.50) | SMN1; SMN2NPC1TP53RAB9ABCL2L1 | |
| SCHEMBL15101089 | 0.85 | PGR (0.56) | PGRMTNR1BMTNR1ASCN9ASMN1; SMN2 | |
| SCHEMBL678831 | 0.85 | BCL2L1 (0.52) | PGRSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL680096 | 0.85 | SMN1; SMN2 (0.48) | PGRSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL678903 | 0.85 | BCL2L1 (0.52) | PGRSCN2BSCN1ASCN1BSCN5A | |
| SCHEMBL16319187 | 0.84 | MAPK14 (0.56) | PGRSCN5ASCN9ASMN1; SMN2NPC1 | |
| SCHEMBL2172190 | 0.84 | NPC1 (0.62) | SCN2BSCN1ASCN1BSCN5ASCN9A | |
| SCHEMBL679785 | 0.84 | MCL1 (0.62) | PGRSCN9ABCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | PGR 3657/4885MTNR1B 579/4885MTNR1A 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.