Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 13/20 | 0.52 |
| ▸ | CYP26B1 | Q9NR63 | 10/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 3/20 | 0.34 |
| ▸ | RARB | P10826 | 3/20 | 0.34 |
| ▸ | RARG | P13631 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737183 | 0.90 | CYP26A1 (0.56) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL14194568 | 0.86 | CYP26A1 (0.36) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL14223679 | 0.86 | CYP26A1 (0.54) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL4850944 | 0.86 | CYP26A1 (0.49) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL13606647 | 0.82 | CYP26A1 (0.50) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL4521493 | 0.82 | CYP26A1 (0.49) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL4521499 | 0.82 | CYP26A1 (0.49) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL4846245 | 0.81 | CYP26A1 (0.33) | CYP26A1CYP26B1 | |
| SCHEMBL5736403 | 0.81 | CYP26A1 (0.61) | CYP26A1CYP26B1FFAR1RXRARXRB | |
| SCHEMBL4849313 | 0.79 | CYP26A1 (0.42) | CYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351737-B2 | 4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity | ALLERGAN, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-7351737-B2 | 4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity | ALLERGAN, INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20040077721-A1 | Compositions and methods using compounds having cytochrome P450RAI inhibitory activity co-administered with vitamin A | ALLERGAN, INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077721-A1 | Compositions and methods using compounds having cytochrome P450RAI inhibitory activity co-administered with vitamin A | RARA, CYP2R1, RXRA | CYP26A1 5/4885CYP26B1 8/4885FFAR1 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.