Sugi Predict

Sugi Predict / Compounds / SCHEMBL6809700

SCHEMBL6809700

SCHEMBL6809700

COc1ccc(S(=O)(=O)Nc2ccccc2)cc1N

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 1/20 0.76
▸ CA9 Q16790 1/20 0.76
▸ CA1 P00915 1/20 0.64
▸ CA2 P00918 1/20 0.64
▸ MMP1 P03956 1/20 0.64
▸ MMP2 P08253 1/20 0.64
▸ MMP9 P14780 1/20 0.64
▸ MMP8 P22894 1/20 0.64
▸ MMP13 P45452 1/20 0.64
▸ HTT P42858 3/20 0.60
▸ MAPT P10636 3/20 0.59
▸ LMNA P02545 3/20 0.57
▸ SMN1; SMN2 Q16637 2/20 0.57
▸ F2 P00734 3/20 0.57
▸ PRSS1 P07477 3/20 0.57
▸ PRSS2 P07478 3/20 0.57
▸ PRSS3 P35030 3/20 0.57
▸ ALDH1A1 P00352 2/20 0.57
▸ KMT2A Q03164 3/20 0.56
▸ PKM P14618 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10947961 0.88 CA12 (0.76) CA12CA9HTTMAPTLMNA
SCHEMBL8752463 0.86 CA12 (1.00) CA12CA9HTTMAPTLMNA
SCHEMBL11594771 0.85 CA12 (0.58) CA12CA9CA1CA2HTT
SCHEMBL2215125 0.84 CA1 (0.62) CA12CA9CA1CA2MMP1
SCHEMBL15647379 0.84 PGR (0.58) CA12CA9HTTSMN1; SMN2KMT2A
Hydrochloric Acid SCHEMBL6339594 0.83 CA1 (0.61) CA12CA9CA1CA2MMP1
SCHEMBL11574937 0.82 MEN1 (0.79) CA12CA9CA1CA2MMP1
SCHEMBL22095988 0.82 CA12 (0.76) CA12CA9HTTMAPTLMNA
SCHEMBL9045755 0.82 CA12 (0.76) CA12CA9HTTMAPTLMNA
SCHEMBL11572158 0.82 HTR6 (0.58) CA12CA9CA1CA2MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042276-B1 THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER LAMBERT CO (US) 2004-11-17 — — EP disclosed
US-6528528-B2 Inhibitors of 15-lipoxygenase, inhibiting chemotaxis of monocytes WARNER-LAMBERT COMPANY 2003-03-04 — — US disclosed
US-20010031874-A1 Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis CONNOR DAVID THOMAS (US) 2001-10-18 — — US disclosed
US-6268387-B1 INHIBITORS OF THE ENZYME 15-LIPOXYGENASE AND ARE INHIBITORS OF MONOCYTE CHEMOTAXIS. WARNER-LAMBERT COMPANY 2001-07-31 — — US disclosed
EP-1042276-A1 THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY LLC (US) 2000-10-11 — — EP disclosed
WO-1999032433-A1 THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1999-07-01 — — WO disclosed
US-5204453-A Process for the preparation of 1:2 metal complex azo compounds by carrying out diazotization and coupling in the presence of a metal donor CIBA-GEIGY CORPORATION (US) 1993-04-20 — — US disclosed
US-5001227-A Fibre-reactive 1:1 chromium complex azo or azomethine dyes having a bidentate chelating group and a monofunctional neutral ligand CIBA-GEIGY CORPORATION (US) 1991-03-19 — — US disclosed
US-4990598-A Colorfastness CIBA-GEIGY CORPORATION, A CORP. OF NEW YORK 1991-02-05 — — US disclosed
US-4960870-A DYEING WOOL, POLYAMIDES; FIBER REACTIVE DYES CIBA-GEIGY CORPORATION (US) 1990-10-02 — — US disclosed
EP-0011048-B1 A PROCESS FOR THE MANUFACTURE OF SUBSTANTIALLY PURE 3-AMINO-4-ALKOXY-ACYLANILIDES FROM 2,4-DINITROCHLOROBENZENE Toms River Chemical Corporation (US) 1982-01-27 — — EP disclosed
US-4283556-A Process for the manufacture of substantially pure 3-amino-4-alkoxy-acylanilides from 2,4-dinitrochlorobenzene TOMS RIVER CHEMICAL CORPORATION (US) 1981-08-11 — — US disclosed
US-4219473-A Substituted unsymmetrical azo, azomethine 1:2 chromium complexes CIBA-GEIGY CORPORATION (US) 1980-08-26 — — US disclosed
EP-0011048-A1 A process for the manufacture of substantially pure 3-amino-4-alkoxy-acylanilides from 2,4-dinitrochlorobenzene Toms River Chemical Corporation (US) 1980-05-14 — — EP disclosed
US-4125368-A Metallized monoazo dyes TOMS RIVER CHEMICAL CORP. (US) 1978-11-14 — — US disclosed
US-4116952-A POLYAMIDES CIBA-GEIGY CORPORATION (US) 1978-09-26 — — US disclosed
US-4092307-A COPPER, NICKEL, COBALT OR CHROMIUM CIBA-GEIGY CORPORATION (US) 1978-05-30 — — US disclosed
US-4058515-A Metallized phenyl-azo-naphthol compounds TOMS RIVER CHEMICAL CORPORATION (US) 1977-11-15 — — US disclosed
US-4033942-A Chromium complex dye, including azo and azo methine dye compounds CIBA-GEIGY AG (CH) 1977-07-05 — — US disclosed
US-3978037-A POLYAMIDES CIBA-GEIGY CORPORATION (US) 1976-08-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010031874-A1 Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis TPMT, CTH, CBS CA12 4639/4885CA9 2420/4885CA1 4089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.