Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 11/20 | 0.61 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | APOB | P04114 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800016 | 0.90 | MTTP (0.62) | MTTPDEGS1PTGS1TRPV1 | |
| SCHEMBL6805714 | 0.88 | MTTP (0.66) | MTTPDEGS1PTGS1TRPV1F10 | |
| SCHEMBL20601640 | 0.88 | SLC6A4 (0.59) | MTTPDEGS1F10CHRNB2CHRNB4 | |
| SCHEMBL31586725 | 0.88 | SLC6A4 (0.59) | MTTPDEGS1F10CHRNB2CHRNB4 | |
| SCHEMBL5235522 | 0.88 | CHRNB2 (0.60) | MTTPDEGS1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6789850 | 0.83 | PTPN1 (0.59) | MTTPPTGS1TRPV1APOBCHRNB2 | |
| SCHEMBL13993522 | 0.83 | MTTP (0.59) | MTTP | |
| SCHEMBL26405652 | 0.82 | PTGES (0.57) | DEGS1PTGS1TRPV1F10PTGES | |
| SCHEMBL6793515 | 0.79 | MTTP (0.63) | MTTPTRPV1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6261203 | 0.79 | MTTP (0.62) | MTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040132745-A1 | Microsomal triglyceride transfer protein inhibitor | PFIZER INC | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132745-A1 | Microsomal triglyceride transfer protein inhibitor | MTTP, CETP, APOB | MTTP 1/4885DEGS1 3761/4885PTGS1 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.