Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746358 | 0.82 | LOXL2 (0.58) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL10483392 | 0.82 | LOXL2 (0.58) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL8688643 | 0.82 | LOXL2 (0.58) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL6810574 | 0.81 | MMP13 (0.44) | LOXL2CYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8567412 | 0.79 | LOXL2 (0.55) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL7762223 | 0.79 | LOXL2 (0.55) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL6805411 | 0.75 | CYP1A2 (0.49) | CYP1A2NCF1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6966651 | 0.73 | LOXL2 (0.60) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL6223283 | 0.73 | LOXL2 (0.71) | LOXL2CYP1A2NCF1KDM4EHTR1A | |
| SCHEMBL7512307 | 0.72 | LOXL2 (0.55) | LOXL2CYP1A2NCF1KDM4EHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |
| WO-2003016248-A2 | BICYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$G(A) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY PATENT DEPARTMENT (US) | 2003-02-27 | — | — | WO | disclosed |