Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809997 | 0.82 | LOXL2 (0.47) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL8567412 | 0.81 | LOXL2 (0.55) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL15453213 | 0.81 | LOXL2 (0.58) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL349073 | 0.81 | LOXL2 (0.58) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL5966208 | 0.81 | LOXL2 (0.58) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL38654646 | 0.81 | LOXL2 (0.58) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL6810574 | 0.78 | MMP13 (0.44) | LOXL2CYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8908672 | 0.78 | LOXL2 (0.55) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL3972788 | 0.78 | LOXL2 (0.64) | LOXL2CYP1A2NCF1HTR1AADRA1D | |
| SCHEMBL805503 | 0.78 | LOXL2 (0.64) | LOXL2CYP1A2NCF1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712274-A | ANTIINFLAMMATORY, ANTIALLERGEN | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-01-27 | — | — | US | disclosed |
| WO-1995011895-A1 | N-BENZOYL-4-OXY/THIO-2-SUBSTITUTED PIPERIDINES AS SUBSTANCE-P RECEPTOR ANTAGONISTS | CIBA-GEIGY AG (CH) | 1995-05-04 | — | — | WO | disclosed |