Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681056 | 0.88 | ALOX5 (0.42) | ALOX5CYP1A2EPHX1CNR1F2 | |
| SCHEMBL12188504 | 0.85 | CYP1A2 (0.41) | ALOX5CYP1A2EPHX1CNR1F2 | |
| SCHEMBL2738521 | 0.85 | ALOX5 (0.40) | ALOX5CYP1A2EPHX1CNR1SMN1; SMN2 | |
| SCHEMBL681418 | 0.82 | ALDH1A1 (0.36) | ALOX5CYP1A2CNR1SMN1; SMN2KMT2A | |
| SCHEMBL681806 | 0.79 | CYP1A2 (0.37) | ALOX5CYP1A2CNR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL680223 | 0.77 | ALOX5 (0.42) | ALOX5CYP1A2EPHX1SMN1; SMN2KMT2A | |
| SCHEMBL681301 | 0.77 | ALOX5 (0.31) | ALOX5CYP1A2 | |
| SCHEMBL17803820 | 0.76 | PKM (0.39) | ALOX5CYP1A2GAAHTT | |
| SCHEMBL680150 | 0.74 | HTR2A (0.43) | ALOX5CYP1A2EPHX1SMN1; SMN2KMT2A | |
| SCHEMBL681405 | 0.73 | ALOX5 (0.38) | ALOX5CYP1A2CNR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |