Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | FPR3 | P25089 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681364 | 0.88 | CYP1A2 (0.34) | ALOX5CYP1A2POLBFPR3FPR2 | |
| SCHEMBL14300655 | 0.85 | CYP1A2 (0.39) | ALOX5CYP1A2 | |
| SCHEMBL12028980 | 0.82 | ALOX5 (0.35) | ALOX5CYP1A2 | |
| SCHEMBL681418 | 0.80 | ALDH1A1 (0.36) | ALOX5CYP1A2 | |
| SCHEMBL681806 | 0.77 | CYP1A2 (0.37) | ALOX5CYP1A2POLB | |
| SCHEMBL681240 | 0.77 | ALOX5 (0.41) | ALOX5CYP1A2 | |
| SCHEMBL17803820 | 0.74 | PKM (0.39) | ALOX5CYP1A2 | |
| SCHEMBL681415 | 0.73 | CHRM2 (0.43) | ALOX5CYP1A2 | |
| SCHEMBL680223 | 0.72 | ALOX5 (0.42) | ALOX5CYP1A2 | |
| SCHEMBL681303 | 0.71 | MEN1 (0.36) | POLBFPR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |