Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6354040 | 0.98 | SLC22A1 (0.52) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Bromide SCHEMBL6812597 | 0.96 | SLC22A1 (0.50) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2477272 | 0.90 | LMNA (0.49) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2480151 | 0.90 | LMNA (0.49) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2477872 | 0.90 | LMNA (0.49) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2482594 | 0.90 | LMNA (0.49) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2484450 | 0.89 | DNM1 (0.52) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2485186 | 0.89 | DNM1 (0.52) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2480274 | 0.89 | DNM1 (0.52) | SLC22A1LMNASLC22A2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL2481683 | 0.89 | DNM1 (0.52) | SLC22A1LMNASLC22A2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030012756-A9 | Use of an organometallic compound to protect and/or strengthen a keratin material, and treatment process | HILTI AKTIENGESELLSCHAFT (LI) | 2003-01-16 | — | — | US | claimed |
| US-6737047-B2 | OBTAINED, FOR EXAMPLE, BY HYDROLYSIS AND CONDENSATION OF METAL ALKOXIDES, INCLUDING | L'OREAL S.A. (FR) | 2004-05-18 | — | — | US | disclosed |
| US-20030012756-A9 | Use of an organometallic compound to protect and/or strengthen a keratin material, and treatment process | HILTI AKTIENGESELLSCHAFT (LI) | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030012756-A9 | Use of an organometallic compound to protect and/or strengthen a keratin material, and treatment process | KRT18, VIM, CDH1 | SLC22A1 4470/4885LMNA 451/4885SLC22A2 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.