Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | P4HB | P07237 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | EPOR | P19235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331246 | 1.00 | MAOB (0.50) | MAOBTHRBL3MBTL1NFE2L2MAPT | |
| SCHEMBL9998122 | 0.87 | TRPV1 (0.43) | MAOBTHRBL3MBTL1EPOR | |
| SCHEMBL9998120 | 0.87 | TRPV1 (0.43) | MAOBTHRBL3MBTL1EPOR | |
| SCHEMBL28669378 | 0.86 | P4HB (0.48) | MAOBTHRBL3MBTL1NFE2L2MAPT | |
| SCHEMBL9998506 | 0.81 | NFE2L2 (0.50) | MAOBNFE2L2MAPTMEN1KMT2A | |
| SCHEMBL9998507 | 0.81 | NFE2L2 (0.50) | MAOBNFE2L2MAPTMEN1KMT2A | |
| SCHEMBL27279242 | 0.81 | MAOB (0.48) | MAOBTHRBL3MBTL1NFE2L2MAPT | |
| SCHEMBL27628628 | 0.81 | LCK (0.49) | MAOBHSP90AA1MAOAFBP1 | |
| SCHEMBL10526143 | 0.80 | MAOB (0.45) | MAOBTHRBL3MBTL1NFE2L2MAPT | |
| SCHEMBL10526138 | 0.80 | MAOB (0.45) | MAOBTHRBL3MBTL1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170805-B1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-8183415-B2 | Methods of synthesizing cinacalcet and salts thereof | AMGEN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2011-11-17 | — | — | US | disclosed |
| US-20090137837-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
| US-20090137837-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
| WO-2009002427-A2 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137837-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | ACE, SI, REN | MAOB 4657/4885THRB 4705/4885L3MBTL1 4359/4885 |
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | ACE, SI, REN | MAOB 4657/4885THRB 4705/4885L3MBTL1 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.