Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646836 | 0.81 | LMNA (0.55) | ALDH1A1LMNAKDM4ESMN1; SMN2GAA | |
| SCHEMBL19915073 | 0.76 | NPSR1 (0.61) | ALDH1A1LMNAKDM4ESMN1; SMN2GAA | |
| SCHEMBL2751300 | 0.75 | ALDH1A1 (0.70) | ALDH1A1LMNAALOX12KDM4ESMN1; SMN2 | |
| SCHEMBL5444729 | 0.74 | LMNA (1.00) | ALDH1A1LMNAALOX12SMN1; SMN2MEN1 | |
| SCHEMBL1639715 | 0.74 | GAA (0.59) | ALDH1A1LMNAKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL11521594 | 0.74 | MAPK10 (0.62) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL2486964 | 0.73 | BRD4 (0.53) | ALDH1A1MEN1KMT2AMAPK1MAPT | |
| SCHEMBL1645759 | 0.73 | DRD2 (0.52) | ALDH1A1LMNAALOX12SMN1; SMN2GAA | |
| SCHEMBL11300182 | 0.73 | GAA (0.54) | ALDH1A1LMNAALOX12KDM4ESMN1; SMN2 | |
| SCHEMBL14715753 | 0.73 | GAA (0.54) | ALDH1A1LMNAALOX12KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077694-B1 | ARYL NITRONE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | RENOVIS INC (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6258852-B1 | NITRONE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISEASE | CENTAUR PHARMACEUTICALS, INC. | 2001-07-10 | — | — | US | disclosed |
| EP-1077694-A1 | ARYL NITRONE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | CENTAUR PHARMACEUTICALS, INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6083989-A | ADMINISTERING TO THE PATIENT SUFFERING FROM INFLAMMATORY BOWL MOVEMENT AN N-SUBSTITUTED ARYL NITRON COMPOUND OR SALT | CENTAUR PHARMACEUTICALS, INC. (US) | 2000-07-04 | — | — | US | disclosed |
| WO-1999059576-A1 | ARYL NITRONE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | CENTAUR PHARMACEUTICALS, INC. (US) | 1999-11-25 | — | — | WO | disclosed |