Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821870 | 0.96 | ENPP1 (0.36) | CRHR1ENPP1HSP90AA1HSP90AB1CRHR2 | |
| SCHEMBL6818769 | 0.88 | FFAR4 (0.35) | CRHR1CCNT1JAK2JAK1 | |
| SCHEMBL6813739 | 0.85 | DYRK1A (0.38) | CRHR1ENPP1DYRK1AJAK2JAK1 | |
| SCHEMBL6817533 | 0.79 | HSP90AA1 (0.37) | CRHR1HSP90AA1HSP90AB1CRHR2CDC7 | |
| SCHEMBL6082630 | 0.78 | IDH2 (0.42) | CRHR1HSP90AA1HSP90AB1DYRK1ACDC7 | |
| SCHEMBL6082635 | 0.78 | IDH2 (0.42) | CRHR1HSP90AA1HSP90AB1DYRK1ACDC7 | |
| SCHEMBL6082839 | 0.76 | IDH2 (0.39) | CRHR1HSP90AA1HSP90AB1DYRK1ACDC7 | |
| SCHEMBL6082842 | 0.76 | IDH2 (0.39) | CRHR1HSP90AA1HSP90AB1DYRK1ACDC7 | |
| SCHEMBL6818798 | 0.76 | ABL1 (0.36) | CRHR1KDRJAK2JAK1JAK3 | |
| SCHEMBL6818015 | 0.76 | ACP1 (0.36) | CRHR1HSP90AA1HSP90AB1CRHR2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |