Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813739 | 0.90 | DYRK1A (0.38) | JAK2JAK1JAK3CRHR1 | |
| SCHEMBL6818769 | 0.84 | FFAR4 (0.35) | ABL1BCRFFAR4JAK2JAK1 | |
| SCHEMBL6082274 | 0.78 | CRHR1 (0.38) | FFAR4IL1BCYP1A2CRHR1SCN5A | |
| SCHEMBL6082269 | 0.78 | CRHR1 (0.38) | FFAR4IL1BCYP1A2CRHR1SCN5A | |
| SCHEMBL6814839 | 0.76 | CRHR1 (0.39) | JAK2JAK1JAK3CYP1A2CRHR1 | |
| SCHEMBL6817680 | 0.75 | TLR7 (0.34) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL6082497 | 0.75 | CYP1A2 (0.42) | FFAR4IL1BCYP1A2SCN5A | |
| SCHEMBL6821870 | 0.73 | ENPP1 (0.36) | JAK2JAK1JAK3CRHR1KDR | |
| SCHEMBL6817777 | 0.72 | BRD4 (0.37) | BRD4JAK2JAK1JAK3CRHR1 | |
| SCHEMBL6083103 | 0.68 | MDM2 (0.39) | FFAR4CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |