Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814839 | 0.88 | CRHR1 (0.39) | JAK2JAK1CCNT1CRHR1 | |
| SCHEMBL6818798 | 0.84 | ABL1 (0.36) | FFAR4JAK2JAK1ABL1BCR | |
| SCHEMBL6821870 | 0.84 | ENPP1 (0.36) | JAK2JAK1CCNT1CRHR1SCN9A | |
| SCHEMBL6083103 | 0.79 | MDM2 (0.39) | FFAR4CRHR1 | |
| SCHEMBL6082522 | 0.75 | KDM4E (0.37) | FFAR4CRHR1 | |
| SCHEMBL6082517 | 0.75 | KDM4E (0.37) | FFAR4CRHR1 | |
| SCHEMBL6813739 | 0.73 | DYRK1A (0.38) | JAK2JAK1CRHR1 | |
| SCHEMBL6082274 | 0.70 | CRHR1 (0.38) | FFAR4CRHR1SCN5A | |
| SCHEMBL6082269 | 0.70 | CRHR1 (0.38) | FFAR4CRHR1SCN5A | |
| SCHEMBL6817674 | 0.69 | CRHR1 (0.36) | FFAR4CCNT1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |