Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818798 | 0.90 | ABL1 (0.36) | CRHR1JAK2JAK1JAK3 | |
| SCHEMBL6814839 | 0.85 | CRHR1 (0.39) | DYRK1AENPP1CRHR1JAK2JAK1 | |
| SCHEMBL6817680 | 0.82 | TLR7 (0.34) | ACP1JAK2JAK1JAK3KMT5A | |
| SCHEMBL6821870 | 0.82 | ENPP1 (0.36) | DYRK1AENPP1CRHR1JAK2JAK1 | |
| SCHEMBL6817777 | 0.81 | BRD4 (0.37) | ENPP1CRHR1JAK2JAK1JAK3 | |
| SCHEMBL6083147 | 0.76 | CRHR1 (0.37) | DYRK1ACRHR1 | |
| SCHEMBL6817533 | 0.75 | HSP90AA1 (0.37) | CRHR1ACP1KMT5A | |
| SCHEMBL6818769 | 0.73 | FFAR4 (0.35) | CRHR1JAK2JAK1 | |
| SCHEMBL6817636 | 0.72 | BRD4 (0.37) | MCHR1NPC1KMT2A | |
| SCHEMBL6818015 | 0.71 | ACP1 (0.36) | CRHR1ACP1NPC1RAB9AKMT5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |