SCHEMBL6821870

SCHEMBL6821870

COc1ccc(-c2ncnc(NCCC3CCC3)c2N)c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
CRHR1 P34998 4/20 0.36
JAK2 O60674 2/20 0.35
JAK1 P23458 2/20 0.35
KDR P35968 3/20 0.35
CHRNB2 P17787 2/20 0.35
CHRNB4 P30926 2/20 0.35
CHRNA3 P32297 2/20 0.35
CHRNA4 P43681 2/20 0.35
EPHA2 P29317 2/20 0.35
EPHB4 P54760 2/20 0.35
DRD4 P21917 1/20 0.35
SLC6A2 P23975 1/20 0.35
KCNH2 Q12809 1/20 0.35
SCN9A Q15858 1/20 0.35
DYRK1A Q13627 1/20 0.35
CRHR2 Q13324 1/20 0.34
CDC7 O00311 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6814839 0.96 CRHR1 (0.39) ENPP1HSP90AA1HSP90AB1CRHR1JAK2
SCHEMBL6818769 0.84 FFAR4 (0.35) CRHR1JAK2JAK1SCN9ACCNT1
SCHEMBL6813739 0.82 DYRK1A (0.38) ENPP1CRHR1JAK2JAK1DYRK1A
SCHEMBL6818015 0.80 ACP1 (0.36) HSP90AA1HSP90AB1CRHR1CHRNB2CHRNB4
SCHEMBL6082842 0.79 IDH2 (0.39) HSP90AA1HSP90AB1CRHR1CHRNB2CHRNB4
SCHEMBL6082839 0.79 IDH2 (0.39) HSP90AA1HSP90AB1CRHR1CHRNB2CHRNB4
SCHEMBL6082635 0.76 IDH2 (0.42) HSP90AA1HSP90AB1CRHR1DYRK1ACDC7
SCHEMBL6082630 0.76 IDH2 (0.42) HSP90AA1HSP90AB1CRHR1DYRK1ACDC7
SCHEMBL6817533 0.76 HSP90AA1 (0.37) HSP90AA1HSP90AB1CRHR1CHRNB2CHRNB4
SCHEMBL6082251 0.73 CRHR1 (0.49) HSP90AA1HSP90AB1CRHR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004031189-A1 PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2004-04-15 WO disclosed