Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641650 | 0.84 | ITGAL (0.43) | ALDH1A1AKR1C3SMN1; SMN2MGLLTHRB | |
| SCHEMBL6568437 | 0.82 | ALDH1A1 (0.40) | HPGDALDH1A1HSD17B10AKR1C3RAB9A | |
| SCHEMBL6309661 | 0.76 | MGLL (0.44) | ALDH1A1RAB9ANPC1SMN1; SMN2MGLL | |
| SCHEMBL6317717 | 0.75 | ITGAL (0.43) | ALDH1A1HSD17B10SMN1; SMN2MAPTMGLL | |
| SCHEMBL6317025 | 0.75 | ITGAL (0.43) | ALDH1A1RAB9ASMN1; SMN2MAPTMGLL | |
| SCHEMBL6312229 | 0.74 | ITGAL (0.49) | HPGDALDH1A1ITGB2ICAM1ITGAL | |
| SCHEMBL6315961 | 0.74 | ITGAL (0.48) | AKR1C3RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6197314 | 0.74 | ITGB2 (0.48) | THRBITGB2ICAM1ITGAL | |
| SCHEMBL6199467 | 0.73 | ITGAL (0.48) | ITGB2ICAM1ITGAL | |
| SCHEMBL6817323 | 0.73 | HTT (0.31) | HPGDALDH1A1MAPTTHRBITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2004-09-08 | — | — | EP | disclosed |