Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818255 | 0.97 | CRHR1 (0.36) | CRHR1CCNT1CRHR2FFAR4PDE4D | |
| SCHEMBL6817533 | 0.88 | HSP90AA1 (0.37) | CRHR1CCNT1CRHR2 | |
| SCHEMBL6818015 | 0.84 | ACP1 (0.36) | CRHR1CCNT1CRHR2 | |
| SCHEMBL6813647 | 0.82 | ACP1 (0.43) | CRHR1CRHR2 | |
| SCHEMBL6817843 | 0.77 | SCN9A (0.37) | CRHR1CCNT1 | |
| SCHEMBL6082116 | 0.77 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6081745 | 0.76 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL6817664 | 0.76 | KMT5A (0.34) | CRHR1ACHE | |
| SCHEMBL6814612 | 0.75 | BCHE (0.30) | BCHEACHE | |
| SCHEMBL6817777 | 0.74 | BRD4 (0.37) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |