SCHEMBL6818167

SCHEMBL6818167

CCCC(=O)N(C)c1cc2c(C(=O)Nc3ccc(C#N)cc3C(=O)O)noc2cc1-c1ccc(NC(C)=O)cc1C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.34
MAP2K1 Q02750 1/20 0.32
PPARG P37231 1/20 0.31
S1PR1 P21453 2/20 0.31
S1PR3 Q99500 2/20 0.31
ALB P02768 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6818364 0.93 RORC (0.34) RORCMAP2K1PPARGS1PR1S1PR3
SCHEMBL6818625 0.93 MAP2K1 (0.34) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6819802 0.91 TP53 (0.33) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6822336 0.90 MAP2K1 (0.33) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6819469 0.87 RORC (0.36) RORCMAP2K1PPARGS1PR1S1PR3
SCHEMBL6833954 0.87 RORC (0.35) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6818583 0.86 RORC (0.33) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6822026 0.86 EGLN2 (0.35) RORCMAP2K1S1PR1S1PR3ALB
SCHEMBL6819608 0.86 GHSR (0.32) ALB
SCHEMBL6818615 0.86 RORC (0.35) RORCMAP2K1PPARGS1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018428-A1 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed