Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819772 | 0.88 | MMP2 (0.44) | POLBNPSR1ITGB3MMP3ITGA2B | |
| SCHEMBL6819770 | 0.88 | MMP2 (0.44) | POLBNPSR1ITGB3MMP3ITGA2B | |
| SCHEMBL6818664 | 0.88 | HDAC3 (0.45) | POLBNPSR1ITGB3ITGAVMMP9 | |
| SCHEMBL23171829 | 0.77 | POLB (0.54) | POLBNPSR1NAAAMMEMMP9 | |
| SCHEMBL31522342 | 0.76 | ITGB3 (0.51) | ITGB3ITGAVITGA2B | |
| SCHEMBL6818957 | 0.76 | ITGB3 (0.51) | ITGB3ITGAVITGA2B | |
| SCHEMBL6819162 | 0.76 | ALDH1A1 (0.43) | POLBNAAAMMP9MMP1MMP3 | |
| SCHEMBL8728179 | 0.73 | SIRT2 (0.47) | POLBITGB3ITGAVITGA2BCNR2 | |
| SCHEMBL22054577 | 0.73 | POLB (0.49) | POLBNPSR1NAAAMMEMMP9 | |
| SCHEMBL22054417 | 0.73 | POLB (0.49) | POLBNPSR1NAAAMMEMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004020402-A1 | SULPHONYLAMINO DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | claimed |
| WO-2004020402-A1 | SULPHONYLAMINO DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | disclosed |