Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954018 | 1.00 | KMT2A (0.41) | KMT2AKDM4EHSD17B10GAALMNA | |
| SCHEMBL6810038 | 1.00 | KMT2A (0.41) | KMT2AKDM4EHSD17B10GAALMNA | |
| SCHEMBL4939718 | 0.95 | KMT2A (0.42) | KMT2AKDM4EHSD17B10GAALMNA | |
| SCHEMBL5026447 | 0.95 | KMT2A (0.42) | KMT2AKDM4EHSD17B10GAALMNA | |
| SCHEMBL4939720 | 0.95 | KMT2A (0.42) | KMT2AKDM4EHSD17B10GAALMNA | |
| SCHEMBL78947 | 0.87 | LMNA (0.48) | KMT2AGAALMNAPOLBCNR1 | |
| SCHEMBL475421 | 0.87 | LMNA (0.48) | KMT2AGAALMNAPOLBCNR1 | |
| SCHEMBL317779 | 0.87 | LMNA (0.48) | KMT2AGAALMNAPOLBCNR1 | |
| SCHEMBL3066907 | 0.81 | LMNA (0.48) | KMT2AKDM4EHSD17B10GAALMNA | |
| Methylene Chloride SCHEMBL28127317 | 0.81 | LMNA (0.47) | KMT2AGAALMNAPOLBCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054996-B1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | SEARLE & CO (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6638758-B2 | Separating enantiomeric lactam esters by selective hydrolyzing one enantiomer by contact with a biocatalyst, such as an enzyme or a microorganism and separating the hydrolysis product from the unreacted lactam esters. | G.D. SEARLE & CO. | 2003-10-28 | — | — | US | disclosed |
| US-20010055798-A1 | Process for the enzymatic resolution of lactams | G.D. SEARLE & CO. | 2001-12-27 | — | — | US | disclosed |
| US-6277626-B1 | LACTAM ESTERS ARE CONTACTED WITH A BIOCATALYST, SUCH AS ENZYME OR A MICROORGANISM, IN SOLUTION WHEREIN ONLY ONE ENANTIOMER IS SELECTIVELY HYDROLYZED TO GIVE OPTICALLY ACTIVE ISOMER OF CORRESPONDING ACID; SEPARATING HYDROLYSIS PRODUCT | G.D. SEARLE & CO. | 2001-08-21 | — | — | US | disclosed |
| EP-1054996-A1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | G.D. SEARLE & CO. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041405-A1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010055798-A1 | Process for the enzymatic resolution of lactams | MGAM, SRR, APEH | KMT2A 2323/4885KDM4E 1546/4885HSD17B10 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.