Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15421267 | 0.84 | NR4A2 (0.56) | HTR3ANR4A2CA12CA1CA2 | |
| SCHEMBL15444634 | 0.82 | NR4A2 (0.55) | HTR3ANR4A2CA12CA1CA2 | |
| SCHEMBL6822481 | 0.81 | SCN9A (0.47) | HTR3ANR4A2SCN9ACA12CA1 | |
| SCHEMBL23812575 | 0.79 | KMT2A (0.53) | HTR3ANR4A2CNR1CNR2 | |
| SCHEMBL15440770 | 0.79 | HTR3A (0.54) | HTR3ANR4A2CA12CA1CA2 | |
| SCHEMBL15420904 | 0.79 | NR4A2 (0.79) | HTR3ANR4A2 | |
| SCHEMBL27685923 | 0.77 | HTR3A (0.42) | HTR3ANR4A2SCN9ACA12CA1 | |
| SCHEMBL2079787 | 0.76 | SCN9A (0.44) | NR4A2SCN9ACA12CA1CA2 | |
| SCHEMBL4002617 | 0.75 | NR4A2 (0.65) | HTR3ANR4A2SCN9ACA12CA1 | |
| SCHEMBL579555 | 0.75 | NR4A2 (0.65) | HTR3ANR4A2SCN9ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | ELBION AG (DE) | 2004-12-30 | — | — | US | claimed |
| US-20040242643-A1 | 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | ELBION AG (DE) | 2004-12-02 | — | — | US | claimed |
| EP-2363128-B1 | Indole modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2016-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242643-A1 | 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | PDE4A, HNMT, PDE4B | HTR3A 40/4885NR4A2 772/4885SCN9A 3133/4885 |
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | HTR5A, HTR4, HNMT | HTR3A 30/4885NR4A2 1311/4885SCN9A 3531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.