⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248098 | 1.00 | — | — | |
| SCHEMBL1830146 | 1.00 | — | — | |
| SCHEMBL28174421 | 0.91 | CASP1 (0.36) | — | |
| SCHEMBL4360002 | 0.79 | — | — | |
| SCHEMBL4359998 | 0.79 | — | — | |
| SCHEMBL1878200 | 0.75 | — | — | |
| SCHEMBL4361308 | 0.75 | — | — | |
| SCHEMBL7603637 | 0.75 | ALDH1A1 (0.35) | — | |
| SCHEMBL7603644 | 0.75 | ALDH1A1 (0.35) | — | |
| SCHEMBL4581398 | 0.74 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112363-A1 | 2-[1-[(2-FLUOROPHENYL)METHYL]-5-(3-ISOXAZOLYL)-1H-PYRAZOL-3-YL]-PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS AS SOLUBLE GUANYLATE CYCLASE (SGC) STIMULATORS FOR THE TREATMENT OF PULMONARY HYPERTENSION | Ironwood Pharmaceuticals, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2797915-B1 | 2-benzyl-3-(oxazole/thiazole)-5-(pyrimidin-2-yl)-1(H)-pyrazole derivatives as stimulators of the soluble guanylate cyclase (sGC) for the treatment of e.g. hypertension or heart failure | IRONWOOD PHARMACEUTICALS INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-20160175307-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-06-23 | — | — | US | disclosed |
| US-9309235-B2 | SGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150342954-A1 | 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150274712-A1 | sGC STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2015-10-01 | — | — | US | disclosed |
| US-9139564-B2 | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| EP-2797915-A1 | 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2014047111-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| WO-2013101830-A1 | 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| EP-1219416-B1 | On-press development printing method using a negative working thermally sensitive lithographic printing plate | AGFA GEVAERT (BE) | 2004-08-04 | — | — | EP | disclosed |
| US-6645705-B2 | Photographic element which includes a support, at least one silver-halide emulsion layer superposed on the support and a processing-solution-permeable overcoat overlying the silver-halide emulsion layer that becomes water-resistant | EASTMAN KODAK COMPANY | 2003-11-11 | — | — | US | disclosed |
| US-20030162138-A1 | Protective overcoat for photographic elements | EASTMAN KODAK COMPANY | 2003-08-28 | — | — | US | disclosed |
| EP-1308777-A1 | Protective overcoat for photographic elements | EASTMAN KODAK COMPANY (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1069473-B1 | Coating composition for a protecting layer for image recording materials | EASTMAN KODAK CO (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1219416-A1 | On-press development printing method using a negative working thermally sensitive lithographic printing plate | Agfa-Gevaert (BE) | 2002-07-03 | — | — | EP | disclosed |
| EP-1069472-A1 | Coating composition for a protecting layer for gelatin based photographic products containing a 1H-pyrazolo-[1,5-b][1,2,4]-triazole-type magenta coupler | EASTMAN KODAK COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6165653-A | Protecting layer for gelatin based photographic products containing 1H-pyrazolo[1,5,-b][1,2,4]triazole-type magenta coupler | EASTMAN KODAK COMPANY (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0981071-A1 | Protective layer for gelatin based AGX photographic products | EASTMAN KODAK COMPANY (US) | 2000-02-23 | — | — | EP | disclosed |
| US-5952130-A | PHOTOGRAPHIC PRODUCT WITH WATER AND FINGERPRINT RESISTANT COATING MADE OF WATER INSOLUBLE POLYMERIC MATERIALS HAVING SPECIFIC GLASS TRANSITION TEMPERATURE CONTAINING A VINYL HALIDE OR AN ACRYLONITRILE MONOMER; ORGANIC SOLVENT-FREE | EASTMAN KODAK COMPANY (US) | 1999-09-14 | — | — | US | disclosed |