Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11507389 | 0.89 | KMT2A (0.41) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL6821927 | 0.87 | POLB (0.47) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL11544325 | 0.86 | THRB (0.41) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL11764920 | 0.85 | KMT2A (0.43) | KMT2AMAPTMEN1LMNANPSR1 | |
| SCHEMBL6822589 | 0.85 | TSHR (0.46) | KMT2AMAPTMEN1LMNAMAPK1 | |
| SCHEMBL31294747 | 0.83 | HSD11B1 (0.41) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL11494029 | 0.81 | KMT2A (0.47) | KMT2ALMNAALDH1A1HPGDHSD11B1 | |
| SCHEMBL11545326 | 0.81 | SLC6A2 (0.41) | KMT2AMAPTLMNANPSR1MAPK1 | |
| SCHEMBL1349277 | 0.80 | TSHR (0.49) | KMT2AMAPTMEN1LMNAHTT | |
| SCHEMBL31294663 | 0.80 | KMT2A (0.46) | KMT2AMAPTMEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737438-B2 | EFFECTIVE IN MULTIDRUG RESISTANT MICE | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-05-18 | — | — | US | disclosed |
| US-20040053991-A1 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof | COUNCIL SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053991-A1 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof | DHPS, TBXAS1, ABCC1 | KMT2A 2972/4885MAPT 3696/4885MEN1 4252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.