Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 6/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823141 | 0.80 | SRD5A1 (1.00) | SRD5A1NOTUMHSD17B3ROCK1 | |
| SCHEMBL6819941 | 0.76 | SRD5A1 (0.46) | SRD5A1NOTUMOPRM1OPRK1OPRL1 | |
| SCHEMBL6823140 | 0.76 | NOTUM (0.45) | SRD5A1NOTUMALDH1A1ROCK1 | |
| SCHEMBL6819871 | 0.72 | SRD5A1 (0.55) | SRD5A1NOTUMALDH1A1OPRM1OPRK1 | |
| SCHEMBL6942297 | 0.69 | SRD5A1 (0.39) | SRD5A1NOTUMALDH1A1OPRM1OPRK1 | |
| SCHEMBL22005465 | 0.68 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL7075121 | 0.68 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL6820047 | 0.68 | SRD5A1 (1.00) | SRD5A1HSD17B3ALDH1A1ROCK1 | |
| SCHEMBL17655192 | 0.67 | SLC6A2 (0.41) | SRD5A1NOTUMHSD17B3ALDH1A1OPRM1 | |
| SCHEMBL6815740 | 0.67 | AADAT (0.38) | SRD5A1NOTUMALDH1A1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | claimed |
| EP-0999747-B1 | USE OF BENZO[C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | APPLIED RESEARCH SYSTEMS (AN) | 2003-04-23 | — | — | EP | claimed |
| US-6514912-B1 | Use of benzo[C]quinolizine derivatives as plant growth regulators | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-02-04 | — | — | US | claimed |
| EP-0999747-A1 | USE OF BENZO C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2000-05-17 | — | — | EP | claimed |
| WO-1999005913-A1 | USE OF BENZO[C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1999-02-11 | — | — | WO | claimed |
| US-6723850-B1 | N-ALKYLATION OF THE THIOAMIDE WITH A VINYL KETONE IN PRESENCE OF A STRONG BASE; 6-CHLORO-(1H)-3,4-DIHYDROQUINOLIN-2-THIONE REACTED WITH ETHYL VINYL KETONE | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-04-20 | — | — | US | disclosed |
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | disclosed |
| US-6555549-B2 | Useful in treating acne, baldness, prostatic cancer and hypertrophy in men and hirsutism in women | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-04-29 | — | — | US | disclosed |
| EP-0999747-B1 | USE OF BENZO[C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | APPLIED RESEARCH SYSTEMS (AN) | 2003-04-23 | — | — | EP | disclosed |
| US-6552034-B2 | Cyclization of a silylated butadiene reacted with a 2-oxo-1,2,3,4-tetrahydroquinoline; acne; alopecia; prostatic cancer and hypertrophy; hirsutism in women; skin and glandular disorders; anticarcinogenic agents | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-04-22 | — | — | US | disclosed |
| EP-0880520-B1 | BENZO [C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5-ALPHA-REDUCTASES INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2003-04-16 | — | — | EP | disclosed |
| US-6514912-B1 | Use of benzo[C]quinolizine derivatives as plant growth regulators | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-02-04 | — | — | US | disclosed |
| US-20010047098-A1 | Benzo[c]quinolizine derivatives, their preparation and use as 5alpha-reductases inhibitors | MERCK SERONO SA (CH) | 2001-11-29 | — | — | US | disclosed |
| US-20010044542-A1 | Benzo [c] quinolizine derivatives, their preparation and use as 5alpha-reductases inhibitors | MERCK SERONO SA (CH) | 2001-11-22 | — | — | US | disclosed |
| US-6303622-B1 | FOR THERAPY OF ACNE, BALDNESS, PROSTATE CANCER, PROSTATIC HYPERTROPHY; HIRSUTISM | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2001-10-16 | — | — | US | disclosed |
| EP-0999747-A1 | USE OF BENZO C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005913-A1 | USE OF BENZO[C]QUINOLIZINE DERIVATIVES AS PLANT GROWTH REGULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1999-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044542-A1 | Benzo [c] quinolizine derivatives, their preparation and use as 5alpha-reductases inhibitors | CYP3A5, CYP51A1, CYP2F1 | SRD5A1 8/4885NOTUM 551/4885HSD17B3 91/4885 |
| US-20010047098-A1 | Benzo[c]quinolizine derivatives, their preparation and use as 5alpha-reductases inhibitors | CYP3A5, CYP51A1, CYP2F1 | SRD5A1 8/4885NOTUM 551/4885HSD17B3 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.