Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820051 | 0.80 | SRD5A1 (0.64) | NOTUMSRD5A1ROCK1 | |
| SCHEMBL6815740 | 0.76 | AADAT (0.38) | NOTUMSRD5A1ALDH1A1LMNA | |
| SCHEMBL6820043 | 0.76 | SRD5A1 (0.67) | NOTUMSRD5A1ALDH1A1ROCK1 | |
| SCHEMBL6820470 | 0.75 | SRD5A1 (0.67) | NOTUMSRD5A1ALDH1A1ACHE | |
| SCHEMBL6815716 | 0.72 | ALDH1A1 (0.41) | NOTUMSRD5A1ALDH1A1ROCK1ACHE | |
| SCHEMBL6819941 | 0.70 | SRD5A1 (0.46) | NOTUMSRD5A1LMNAMAPT | |
| SCHEMBL7075121 | 0.68 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1LMNAHTT | |
| SCHEMBL22005465 | 0.68 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1LMNAHTT | |
| SCHEMBL14733729 | 0.67 | ROCK1 (0.50) | NOTUMALDH1A1ROCK1LMNAHTT | |
| SCHEMBL11995386 | 0.67 | ROCK1 (0.50) | NOTUMALDH1A1ROCK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | claimed |
| US-6723850-B1 | N-ALKYLATION OF THE THIOAMIDE WITH A VINYL KETONE IN PRESENCE OF A STRONG BASE; 6-CHLORO-(1H)-3,4-DIHYDROQUINOLIN-2-THIONE REACTED WITH ETHYL VINYL KETONE | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-04-20 | — | — | US | disclosed |
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | disclosed |