Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 8/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815716 | 0.77 | ALDH1A1 (0.41) | SRD5A1NOTUMALDH1A1ROCK1 | |
| SCHEMBL6822926 | 0.77 | OPRM1 (0.43) | SRD5A1NOTUMALDH1A1OPRM1OPRK1 | |
| SCHEMBL6820043 | 0.72 | SRD5A1 (0.67) | SRD5A1NOTUMALDH1A1OPRM1OPRK1 | |
| SCHEMBL6822784 | 0.71 | SRD5A1 (1.00) | SRD5A1 | |
| SCHEMBL11995386 | 0.66 | ROCK1 (0.50) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL14733729 | 0.66 | ROCK1 (0.50) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL15965528 | 0.66 | ROCK1 (0.50) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL22005465 | 0.64 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1 | |
| SCHEMBL7167355 | 0.64 | SLC6A2 (0.44) | NOTUMALDH1A1OPRM1OPRK1OPRL1 | |
| SCHEMBL7075121 | 0.64 | ROCK1 (0.51) | NOTUMALDH1A1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | claimed |
| US-6723850-B1 | N-ALKYLATION OF THE THIOAMIDE WITH A VINYL KETONE IN PRESENCE OF A STRONG BASE; 6-CHLORO-(1H)-3,4-DIHYDROQUINOLIN-2-THIONE REACTED WITH ETHYL VINYL KETONE | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-04-20 | — | — | US | disclosed |
| EP-1102765-B1 | PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2003-09-17 | — | — | EP | disclosed |