Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174589 | 1.00 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| Bromide SCHEMBL15398508 | 0.98 | TSHR (0.38) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL31718392 | 0.83 | SIGMAR1 (0.37) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL6880337 | 0.83 | HTR1A (0.47) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6880115 | 0.79 | HTR1A (0.41) | ALDH1A1MAPTKDM4ELMNATDP1 | |
| SCHEMBL10333062 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL387883 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL5164785 | 0.78 | HSD17B10 (0.42) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL4630050 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL2204568 | 0.77 | LMNA (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737409-B2 | FOR CANCER THERAPY | HOFFMANN-LA ROCHE INC. | 2004-05-18 | — | — | US | disclosed |
| US-20030055002-A1 | Dolastatin 10 derivatives | HOFFMANN-LA ROCHE INC. | 2003-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055002-A1 | Dolastatin 10 derivatives | DAD1, DDOST, NPC1 | ALDH1A1 2366/4885MAPT 3505/4885SMN1; SMN2 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.