Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 7/20 | 0.73 |
| ▸ | TUBB | P07437 | 7/20 | 0.73 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.73 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.73 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.73 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.73 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.73 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.73 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.73 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.73 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.73 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.73 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.73 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.73 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | TUBB8B | A6NNZ2 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14386810 | 1.00 | TUBB4A (0.73) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL29748655 | 1.00 | TUBB4A (0.73) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL10083619 | 0.89 | TUBB4A (0.59) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL676698 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL676699 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL12635400 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL29584050 | 0.84 | TUBB4A (1.00) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL10073424 | 0.83 | TUBB4A (0.55) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL23418632 | 0.82 | CYP3A4 (0.70) | TUBB4ATUBBTUBB4BTUBB3TUBB2A | |
| SCHEMBL676906 | 0.75 | TUBB4A (0.83) | TUBB4ATUBBTUBB4BTUBB3TUBB2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841317-B2 | Noscapine and analogs and methods related thereto | EMORY UNIVERSITY (US) | 2014-09-23 | — | — | US | disclosed |
| US-8841317-B2 | Noscapine and analogs and methods related thereto | EMORY UNIVERSITY (US) | 2014-09-23 | — | — | US | disclosed |
| US-20120053199-A1 | NOSCAPINE AND ANALOGS AND METHODS RELATED THERETO | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-03-01 | — | — | US | disclosed |
| US-20110274651-A1 | Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition | EMORY UNIVERSITY (US) | 2011-11-10 | — | — | US | disclosed |
| US-20110274651-A1 | Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition | EMORY UNIVERSITY (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053199-A1 | NOSCAPINE AND ANALOGS AND METHODS RELATED THERETO | NOS2, NOS1, NOS3 | TUBB4A 3007/4885TUBB 3641/4885TUBB4B 3401/4885 |
| US-20110274651-A1 | Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition | NOS1, NOS2, TBCA | TUBB4A 13/4885TUBB 8/4885TUBB4B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.