Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821990 | 0.83 | SPHK1 (0.39) | SPHK1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL6719418 | 0.81 | GPR119 (0.38) | GPR119SPHK1KMT2AATMMAPK1 | |
| SCHEMBL2081890 | 0.79 | SPHK1 (0.41) | GPR119SPHK1KMT2AJAK2JAK1 | |
| SCHEMBL2081892 | 0.79 | SPHK1 (0.41) | GPR119SPHK1KMT2AJAK2JAK1 | |
| SCHEMBL4444035 | 0.79 | SIGMAR1 (0.42) | GPR119SPHK1KMT2AATMMAPK1 | |
| SCHEMBL2082664 | 0.79 | SPHK1 (0.39) | GPR119SPHK1BRD4 | |
| SCHEMBL2082667 | 0.79 | SPHK1 (0.39) | GPR119SPHK1BRD4 | |
| SCHEMBL2082536 | 0.78 | GPR119 (0.36) | GPR119SPHK1KMT2ABRD4 | |
| SCHEMBL2082537 | 0.78 | GPR119 (0.36) | GPR119SPHK1KMT2ABRD4 | |
| SCHEMBL2079201 | 0.78 | SLC6A2 (0.40) | GPR119SPHK1JAK2JAK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |